Lateral hypothalamic activity indicates hunger and satiety states in humans
نویسندگان
چکیده
Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader-Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food-related cues induced an increase in beta/low-gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha-frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity.
منابع مشابه
Neural Ensemble Coding of Satiety States
The motivation to start or terminate a meal involves the continual updating of information on current body status by central gustatory and reward systems. Previous electrophysiological and neuroimaging investigations revealed region-specific decreases in activity as the subject's state transitions from hunger to satiety. By implanting bundles of microelectrodes in the lateral hypothalamus, orbi...
متن کاملAnand B K & Brobeck J R. Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med. 24:123-40, 1951
Bilateral destructions of a well localised area in lateral hypothalamus led to complete cessation of eating, while lesions involving ventromedial nuclei or the region between these and lateral area produced hyperphagia and obesity. The lateral region (hunger mechanism) was designated 'feeding center' and the medial (inhibitory control) 'satiety center.' [The SCI indicates that this paper has be...
متن کاملHunger and Satiety Gauge Reward Sensitivity
Many of the neurocircuits and hormones known to underlie the sensations of hunger and satiety also substantially alter the activity of the dopaminergic reward system. Much interest lies in the ways that hunger, satiety, and reward tie together, as the epidemic of obesity seems tied to the recent development and mass availability of highly palatable foods. In this review, we will first discuss t...
متن کاملMechanisms controlling feed intake in ruminants: a review.
The purpose of this paper is to review our understanding of the involvement of central and peripheral factors in the control of feed intake in ruminants. The regulation of body weight under various states of energy need depends on an animal's ability to control feed intake to meet these needs. In the central nervous system (CNS), the ventromedial and lateral hypothalamus appear to be the areas ...
متن کاملSatiety does not affect gustatory activity in the nucleus of the solitary tract of the alert monkey.
Feeding to satiety decreases the acceptability of the taste of food. In order to determine whether the responsiveness of gustatory neurons in the nucleus tractus solitarius (NTS) is influenced by hunger, neural activity in the NTS was analyzed while monkeys were fed to satiety. Gustatory neural activity to glucose, fruit juice, NaCl, HCl and quinine HCl was measured before, while and after the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017